作者：Jie Zhao, Qiang Shi, Shifang Luan, Lingjie Song, Huawei Yang, Paola Stagnaro and Jinghua Yin*
关键字：2-Methacryloyloxyethyl phosphorylcholine; Hemocompatibility; Graft copolymerization; Polypropylene non-woven fabric (NWF) membrane; Redox graft polymerization
论文来源：期刊
发表时间：2012年
Surface modification of polypropylene non-woven fabric membrane (NWF) for improving its hemocompatibility was developed by grafting a biomimic monomer, 2-methacryloyloxyethyl phosphorycholine (MPC). The NWF membrane surface was first activated by potassium peroxydisulfate to form hydroxyl groups, and then grafted with MPC using ceric (IV) ammonium nitrate as the redox initiator. The surface chemical changes before and after modification were confirmed by Fourier transform infrared spectroscopy with an AIR unit (FTIR-ATR) and X-ray photoelectron spectroscopy (XPS): the water contact angle results showed the gradual changes in wettability from hydrophobic to hydrophilic surface. Meanwhile, the hemocompatibility of these samples was also evaluated by protein adsorption and platelet adhesion. These experimental results exhibited that the introduction of poly(MPC) onto the NWF membrane surfaces substantially improved their hemocompatibility. The feasibility and simplicity of this procedure may lead to potential applications of NWF membranes in biomedical separation and blood purification. (C) 2012 Elsevier B.V. All rights reserved.