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【2022年影响因子/JCR分区:10.041/Q1】《APPLIED MATERIALS TODAY》Metal-organic framework (MOF)-based slippery liquid-infused porous surface (SLIPS) for purely physical antibacterial applications
作者:Lingwan Haoa,b , Rujian Jianga,b , Jie Gaoa , Jia-ning Xuc , Limei Tiana , Xu Zhange , Shengzhu Zhou
关键字:Slippery liquid-infused porous surfaces ,Antibacterial ,MOF films ,Mechanical sterilization
论文来源:期刊
具体来源:APPLIED MATERIALS TODAY
发表时间:2022年

Medical device-associated infections, caused by bacterial adhesion and biofilm formation, remain a leading threat to public healthcare due to continuous emergence of drug-resistant pathogens. Slippery liquidinfused porous surface (SLIPS) is deemed as a promising mean to reduce colonization of bacteria by exceptional repellency property. However, such inert and mono-functional surface becomes helpless once bacterial adhesion occurs. Here, we report a zeolitic imidazolate framework-L (ZIF-L)-based SLIPS (ZLS) with both anti-biofouling and bactericidal activity that all performances are derived from purely physical interactions. Assembled on various substrates, the porous ZIF-L layer is not only the foundation for constructing SLIPS , but exhibits the mechanical bactericidal activity. Fabricating on the catheters, the ZLS exhibit good biocompatibility and can be utilized in a mice subcutaneous implanted model of infection in vivo without inducing the inflammatory response. Thus, we anticipate that the ZLS could provide a new insight into multifunctional and bactericide-free antibacterial surface modifications