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Polymer Blends and Composites for Biodegradable Coronary Stents and Tissue Scaffolds  
Polymer Blends and Composites for Biodegradable Coronary Stents and Tissue Scaffolds
资料类型: PDF文件
关键词: Biodegradable  PLLA  Tissue  scaffolds  
资料大小: 72K
所属学科: 通用高分子材料
来源: 来源网络
简介:
Inseveralbranchesofthemedicalfield,fromcardiologyorthopaedicstotissueengineering,therehasbeenanincreasingtrendintheuseofbiodegradablematerialsinplaceoftraditional,biostablematerials,suchasmetals,ceramicsandsyntheticpolymers.Biodegradablepolymersandtheircompositesareprominentintheseareasandareofgreatinterestforresearchbecausethereismuchroomforimprovement.Thispaperwillfocusontheapplicationofpolymerblendsandcompositesinbioabsorbablestentsandtissuescaffolds.PLLAisveryprominentinthefieldofbioabsorbablestentsbutitsuffersfrombrittlenesswhichmustbemitigated.OnemethodofdoingthisistoblendPLLAwithrubberypolymerstocreateductileblendswhichstrikeabalancebetweenductility,strength,modulusanddegradationcharacteristics.Thispaperdiscussesthedevelopmentoftheirmechanicalcharacteristics,fromYoung‘smodulustocreep,whichoccursduringdegradation.PLLAisalsoacommonmaterialunderinvestigationfortissuescaffolds.Alargeproportionofworkinthisareafocusesonelectrospinningtocreatetissuescaffoldsbutthisrequirestheuseoforganicsolvents.AprocessforproducingscaffoldswithouttheuseoforganicsolventshasbeendevelopedattheCentreforAdvancedCompositeMaterials,TheUniversityofAuckland.Theprocessinvolvesdrawingofanextrudedpolymercompositefilamenttofibrilisethedispersedphase.Afterproducinganetworkofmicro-/nano-fibrilsthroughacommonmanufacturingtechnique,thematrixisremovedviadissolutioninwater,leavinga3-Dfibrillar,nanoporousnetwork.Thisnetworkcanbeusedasatissuescaffoldwiththeadvantageoverelectrospunnetworksofhavingnoresidualorganicsolventcontent.Thispaperdescribestheprocessofscaffoldmanufacturingwithsomeresultsofin-vitrocellculture.
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