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Preparation of biocompatible nanocapsules with temperature-responsive and bioreducible properties.  
Preparation of biocompatible nanocapsules with temperature-responsive and bioreducible properties.
资料类型: PDF文件
关键词: Stimuli-responsive  nanocapsule  drug  delivery  
资料大小: 516k
所属学科: 高分子化学
来源: 来源网络
简介:
Stimuli-responsive biocompatible nanocarriers are very promising for controlled drug release. Here, wereport redox- and temperature-responsive biocompatible nanocapsules prepared by growinga temperature-responsive biocompatible shell from 3-(trimethoxysilyl)propyl methacrylate-modifiedsilica nanoparticles (SiO2-MPS) via precipitation polymerization, cross-linking the shell withbioreducible chemical linkages, and subsequently removing the silica core by hydrofluoric acid etching.The produced nanocapsules are redox- and temperature-responsive. TEM, FT-IR, TGA, and XPSwere used to characterize the nanocapsules. Dynamic light scattering (DLS) was performed todemonstrate the bioreducible and temperature-responsive properties of the nanocapsules. The lowercritical solution temperature (LCST) of the nanocapsules can be tuned precisely. Fluoresceinisothiocyanate (FITC) was encapsulated into the nanocapsules and used as a model drug molecule todemonstrate the controlled release behavior under external stimuli.
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上传时间: 2016-3-6 10:48:45
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