Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications
作者：Xiangkui Ren, Yakai Feng,* Jintang Guo, Haixia Wang, Qian Li, Jing Yang, Xuefang Hao
关键字：Surface modification
论文来源：期刊
具体来源：Chemical Society Reviews, 2015,44, 5680-5742
发表时间：2015年
Surface modification and endothelialization of vascular biomaterials are two usually used approaches to resist the nonspecific adhesion of proteins, and to improve hemocompatibility and long term patency of artificial vascular grafts. Surface modification of vascular biomaterials by hydrophilic poly(ethylene glycol), zwitterionic polymers, gelatin, heparin and other bioactive molecules can efficiently enhance the hemocompatibility, and can resist platelet adhesion on artificial vascular grafts. However, these modified surfaces exhibit high hydrophilicity so the vascular endothelial cells can not adhere and form a stable endothelial layer on them. Therefore, rapid endothelialization of these biomaterials by specific peptides and gene delivery is now arousing more and more interest. Several active peptides, such as RGD, CAG, REDV, YIGSR etc. can specifically be recognized by endothelial cells. The biomaterials and gene carriers modified by these peptides can exhibit targeting selectivity for the adhesion of endothelial cells. The genes may be delivered by targeting carriers to specific tissues to enhance the promotion and regeneration of blood vessels. A variety of non-viral gene vectors, growth factors and target genes have been investigated for angiogenesis by gene engineering. In this review, we will summarize the recent development of the surface modification and endothelialization of biomaterials in vascular tissue engineering application. The gene engineering and targeting ligand immobilization are the promising methods to enhance the clinical application of artificial vascular grafts.