Education
9/1995-7/1998 Organic Chemistry, Ph.D., Institute of Photographic Chemistry, the Chinese Academy of Sciences, Beijing, China.
9/1992-4/1995 Applied Chemistry, MS, Beijing Institute of Technology (BIT), Beijing, China
9/1988-7/1992 Chemistry, BS, Henan Normal University, Henan, China
CAREER HISTORY
11/2010-present Invited Chair in Nanotechnology at University of Madeira (UMa)/Centro de Química da Madeira (CQM), Portugal.
6/2008-present Professor of special appointment, Shanghai Eastern Scholar, College of Chemistry, Chemical Engineering, and Biotechnology, Donghua University, Shanghai, China.
5/2008-8/2008 Research Assistant Professor. Michigan Nanotechnology Institute for Medicineand Biological Sciences (formerly Center for Biologic Nanotechnology), University of Michigan, USA
6/2005-5/2008 Research Investigator. Michigan Nanotechnology Institute for Medicine and Biological Sciences (formerly Center for Biologic Nanotechnology), University of Michigan,USA
5/2003-5/2005 Research Associate II. Center for Biologic Nanotechnology, University of Michigan, USA
5/2002-5/2003 Research fellow. Center for Biologic Nanotechnology, University of Michigan.
5/2001-5/2002 Visiting scholar in California State University, Los Angeles, USA
5/2000-5/2001 Max-Planck Research Fellow, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
9/1998-5/2000 Postdoctoral Research Fellow, Molecular and Nano Science Laboratory, Department of Physics, Tsinghua University, Beijing, China.
SCIENTIFIC COMMUNITY SERVICE
- Invited to serve as a reviewer for 59 scientific journals (review 50-60 manuscripts every year) including:
Nature Nanotechnology, Journal of the American Chemical Society, Nano Letters, Advanced Materials, Biomaterials, Small, Nanomedicine, Chemical Communications, Biomacromolecules, Journal of Materials Chemistry, Lab on a Chip, Journal of Physical Chemistry B, Journal of Physical Chemistry C, Journal of Physical Chemistry Letters, Molecular Pharmaceutics, Molecular Biosystems, Green Chemistry, Langmuir, ACS Applied Materials & Interfaces, Environmental Science &Technology, Analyst, Nanotechnology, Dalton Transactions, Soft Matter, Physical Chemistry Chemical Physics, Laboratory Investigation, Bioorganic & Medicinal Chemistry, CrystEngComm, Chemosphere, European Journal of Inorganic Chemistry, Colloids and Surfaces A: Physicochemical Engineering Aspects, Journal of Optics A: Pure and Applied Optics, Polymer Bulletin, Chemistry - A European Journal, Journal of Physics: Condensed Matter, Molecules, Analytical Methods, Journal of Nanoscience and Nanotechnology, Acta Biomaterialia, Journal of Membrane Science, Journal of Environmental Monitoring, Organic & Biomolecular Chemistry, Journal of Physics D: Applied Physics, Nanotechnology, Science and Applications, IEEE Engineering in Medicine and Biology Magazine, New Journal of Chemistry, Polymer International, Materials Research Bulletin, European Journal of Nuclear Medicine and Molecular Imaging, Journal of Alloys and Compounds, International Journal of Nanomedicine, Express Polymer Letters, Main Group Chemistry, Journal of Nanomaterials, Letters in Drug Design & Discovery, Nano-Micro Letters, Chinese Chemical Letters, 化学学报, 化学进展, 中国组织工程研究与临床康复.
- Invited to serve as one of the Biocomposite Session Chairs for 14th International Conference on Composites /Nano Engineering (ICCE - 14), July 2-8, 2006, Boulder, Colorado, USA.
- Invited to evaluate the Year 2006 activity report of Centro de Química da Madeira,
Departamento de Química da Universidade da Madeira, PORTUGAL.
- Invited to be on the scientific advisory board for Centro de Química da Madeira
Departamento de Química da Universidade da Madeira Campus da Penteada 9000-390 Funchal PORTUGAL on June 21, 2007.
- Invited to serve as a reviewer to review grant proposals submitted to National Nature Science Foundation of China.
- Invited to serve as a reviewer to review research grant proposal submitted to Office of Research, National University of Singapore (NUS).
- Invited to serve as a reviewer to review research grant proposal submitted to Alberta Nanotechnology Industrial Research Partnership Program.
- Editorial Board:
Journal of Modern Textile Science and Engineering,中国组织工程研究与临床康复.
HONORS AND AWARDS
1988-1992: University undergraduate scholarships,
2000-2001: Max-Planck Fellowship, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany.
2003: Marquis Who’s Who in Science and Engineering,
2005: Inclusion in Who's Who in America,
2006: Who’s Who of Emerging Leaders.
2008: Shanghai Eastern Scholar, Shanghai Municipal Education Commission
2009: Honored as one of the top 10 “nano star” scientists in China, SCOPUS Seeking future nanoscience star activity.
2010: Invited Chair in Nanotechnology at University of Madeira (UMa)/Centro de Química da Madeira (CQM), Supported by FCT-UMa/Santander Bank.
MEMBERSHIPS
American Chemical Society
Sigma Xi (The Scientific Research Society)
Michigan Nanotechnology Institute for Medicine and Biological Sciences (MNIMBS) (http://www.nano.med.umich.edu/Members/Xiangyang-Shi%20.html)
Chinese Chemical Society
Chinese Biomaterials Society
Selected publication:
1. Wen Jin, Xiangyang Shi, Frank Caruso. High Activity Enzyme Microcrystal Multilayer Films.J. Am. Chem. Soc. 2001,123, 8121-8122.
2. Frank Caruso,Xiangyang Shi, Rachel A. Caruso, Andrei Susha. Hollow Titania Spheres from Layered Precursor Deposition on Sacrificial Colloidal Core Particles. Advanced Materials 2001, 13, 740-744.
3. Xiangyang Shi,* Wanyun Ma, Caomin Sun, Shikang Wu. The aggregation behavior of collagen in aqueous solution and its property of stabilizing liposomes in vitro. Biomaterials 2001, 22 (12): 1627-1634.
4. Xiangyang Shi, Shubo Han, Raymond J. Sanedrin, Cesar Galvez, David G. Ho, Billy Hernandez, Feimeng Zhou, Matthias Selke. Formation of Cobalt Oxide Nanotubes: Effect of Intermolecular Hydrogen Bonding Between Co(III) Complex Precursors Incorporated onto Colloidal Templates. Nano Lett. 2002, 2, 289-293.
5. Xiangyang Shi, Shubo Han, Raymond J. Sanedrin, Feimeng Zhou, Matthias Selke. Synthesis of Cobalt Oxide Nanotubes from Colloidal Particles Modified with a Co(III)-Cysteinato Precursor. Chem. Mater. 2002, 14, 1897-1902.
6. Shubo Han, Xiangyang Shi, Feimeng Zhou. Polyelectrolyte Hollow Sphere Lithographic Patterning of Surfaces: Construction of 2-Dimensional Well-Ordered Metal Arrays. Nano Lett. 2002, 2, 97-100.
7. Xiangyang Shi,* Mingwu Shen, Helmuth Moehwald. Polyelectrolyte multilayer nanoreactors toward the synthesis of diverse nanostructured materials. Invited review. Prog. Polym. Sci. 2004, 29, 987-1019.
8. Mohammad T. Islam, Xiangyang Shi, Lajos P. Balogh, James R. Baker jr. HPLC separation of different generations of poly(amidoamine) (PAMAM) dendrimers modified with various terminal groups. Anal. Chem. 2005, 77, 2063-2070
9. Xiangyang Shi, Istvan J. Majoros, James R. Baker Jr. Capillary Electrophoresis of Poly(amidoamine) Dendrimers: From Simple Derivatives to Complex Multi-functional Medical Nanodevices.Invited review. Mol. Pharmaceutics 2005, 2, 278-294.
10. Wojciech Lesniak, Anna Bielinska, Kai Sun, Katarzyna Janczak, Xiangyang Shi, James R. Baker, Jr., Lajos Balogh. Silver/Dendrimer Nanocomposites as Biomarkers: Fabrication,Characterization, In Vitro Toxicity and Intracellular Detection. Nano Lett. 2005, 5, 2123-2130.
11. Xiangyang Shi, István J. Majoros, Anil K. Patri, Xiangdong Bi, Mohammad T. Islam, Ankur Desai, T. Rose Ganser, James R. Baker, Jr. Molecular heterogeneity analysis of poly(amidoamine) dendrimer-based mono- and multifunctional nanodevices by capillary electrophoresis. Analyst 2006, 131, 374-381.
12. Xiangyang Shi, Suhe Wang, Xisui Chen, Sasha Meshinchi, James R. Baker Jr. Encapsulation of Submicrometer-Sized 2-Methoxyestradiol Crystals into Polymer Multilayer Capsules for Biological Applications. Mol. Pharmaceutics 2006, 3, 144-151.
13. Xiangyang Shi, Kai Sun, Lajos Balogh, James R. Baker, Jr. Synthesis, Characterization, and Manipulation of Dendrimer-Stabilized Iron Sulfide Nanoparticles. Nanotechnology 2006, 17, 4554-4560
14. Xiangyang Shi,* Suhe Wang, Haiping Sun, James R. Baker Jr.* Improved Biocompatibility of Dendrimer-Entrapped Gold Nanoparticles. Soft Matter 2007, 3, 71-74
15. Xiangyang Shi,* Suhe Wang,*Sasha Meshinchi,Mary E. Van Antwerp,Xiangdong Bi, Inhan Lee,James R. Baker, Jr*.Dendrimer-Entrapped Gold Nanoparticles as a Nanoplatform for Cancer-Cell Targeting and Imaging. Small 2007, 3, 1245-1252.
16. Su He Wang*, Xiangyang Shi*, Mary Van Antwerp, Zhengyi Cao,Scott D. Swanson, Xiangdong Bi, James R. Baker, Jr.* Dendrimer-Functionalized Iron Oxide Nanoparticles for Specific Targeting and Imaging of Cancer Cells. Adv. Funct. Mater.2007, 17, 3403-3050.
17. Xiangyang Shi*, Inhan Lee, James R. Baker, Jr*. Acetylation of dendrimer-entrapped gold and silver nanoparticles. J. Mater. Chem. 2008, 18, 586-593.
18. Xiangyang Shi*, Su He Wang*, Scott D. Swanson,Song Ge, Zhengyi Cao, Mary Van Antwerp, Kevin J Landmark, James R. Baker, Jr*. Dendrimer-functionalized shell-crosslinked iron oxide nanoparticles for in vivo magnetic resonance imaging of tumors. Adv. Mater., 2008, 20, 1671-1678.
19. Xiangyang Shi, Kai Sun, and James R. Baker, Jr. Spontaneous Formation of Functionalized Dendrimer-Stabilized Gold Nanoparticles. J. Phys. Chem. C. 2008, 112, 8251-8258.
20. Mingwu Shen, Su He Wang, Xiangyang Shi, Xisui Chen, Qingguo Huang, Elijah J. Petersen, Roger A. Pinto, James R. Baker, Jr., and Walter J. Weber, Jr. Polyethyleneimine-Mediated Functionalization of Multi-Walled Carbon Nanotubes: Synthesis, Characterization, and in vitro Toxicity Assay. J. Phys. Chem. C 2009, 113(8), 3150-3156.
21. Xiangyang Shi*, Su He Wang, Mingwu Shen, Mary E. Antwerp, Xisui Chen, Chang Li, Elijah J. Petersen, Qingguo Huang, Walter J. Weber, Jr., and James R. Baker, Jr. Multifunctional Dendrimer-Modified Multi-Walled Carbon Nanotubes: Synthesis, Characterization, and in vitro Cancer Cell Targeting and Imaging. Biomacromolecules 2009, 10, 1744-1750.
22. Seungpyo Hong, Rahul Rattan, István J. Majoros, Douglas G. Mullen, Jennifer L. Peters, Xiangyang Shi, Ania Bielinska, Luz Blanco, Bradford G. Orr, James R. Baker, Jr., and Mark M. Banaszak Holl*. Exploring Membrane Porosity and Cellular Internalization Mechanisms of Poly(amidoamine) Dendrimers: the Role of Sphingolipid GM1. Bioconjugate Chem. 2009, 20(8), 1503-1513
23. Shili Xiao, Mingwu Shen, Rui Guo, Shanyuan Wang, and Xiangyang Shi*. Immobilization of Zero-Valent Iron Nanoparticles into Electrospun Polymer Nanofibers: Synthesis, Characterization, and Potential Environmental Applications. J. Phys. Chem. C 2009, 113, 18062-18068
24. Rui Guo, Han Wang, Chen Peng, Mingwu Shen, Minjie Pan, Xueyan Cao, Guixiang Zhang*, Xiangyang Shi*. X-Ray Attenuation Property of Dendrimer-Entrapped Gold Nanoparticles. J.Phys. Chem. C 2010, 114(1), 50-56
25. Hong Yang, Cuixia Zhang,Xiangyang Shi,* He Hu, Xiaoxia Du, Yong Fang, Yanbin Ma,*Huixia Wu, Shiping Yang*. Water-soluble superparamagnetic manganese ferrite nanoparticles for magnetic resonance imaging. Biomaterials 2010, 31, 3667-3673
26. Hong Yang, Yeming Zhuang, He Hu, Xiaoxia Du, Cuixia Zhang, Xiangyang Shi,*Huixia Wu, and Shiping Yang*. Silica-Coated Manganese Oxide Nanoparticles as a Platform for Targeted Magnetic Resonance and Fluorescence Imaging of Cancer Cells.Adv. Funct. Mater. 2010, 20, 1733-1741
27. Xiangyang Shi*, Inhan Lee, Xisui Chen, Mingwu Shen, Shili Xiao, Meifang Zhu, and James R. Baker, Jr., Su He Wang*. Influence of dendrimer surface charge on the bioactivity of 2-methoxyestradiol complexed with dendrimers.Soft Matter 2010, 6, 2539-2545
28. Shili Xiao, Mingwu Shen, Rui Guo, Qingguo Huang, Shanyuan Wang, Xiangyang Shi*. Fabrication of Multiwalled Carbon Nanotube-Reinforced Electrospun Polymer Nanofibers Containing Zero-Valent Iron Nanoparticles for Environmental Applications. J. Mater. Chem. 2010, 20, 5700-5708
29. Mingwu Shen and Xiangyang Shi*. Dendrimer-based organic/inorganic hybrid nanoparticles in biomedical applications. Nanoscale 2010, 2, 1596-1610
30. Ruiling Qi, Rui Guo, Mingwu Shen, Xueyan Cao, Leqiang Zhang, Jiajia Xu, Jianyong Yu, Xiangyang Shi*. Electrospun Poly(lactic-co-glycolic acid)/Halloysite Nanotube Composite Nanofibers for Drug Encapsulation and Sustained Release. J. Mater. Chem. 2010, 20, 10622-10629
31. Han Wang, Linfeng Zheng, Chen Peng, Rui Guo, Mingwu Shen, Xiangyang Shi*, Guixiang Zhang*. Computed Tomography Imaging Of Cancer Cells Using Acetylated Dendrimer-Entrapped Gold Nanoparticles. Biomaterials 2011, 32, 2979-2988
32. Yin Wang, Rui Guo, Xueyan Cao, Mingwu Shen, and Xiangyang Shi Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy. Biomaterials 2011, 32, 3322-3329
33. Xu Fang,Hui Ma, Shili Xiao,Mingwu Shen,Rui Guo,Xueyan Cao,and Xiangyang Shi*.Facile Immobilization of Gold Nanoparticles into Electrospun Polyethyleneimine/Polyvinyl Alcohol Nanofibers for Catalytic Applications. J. Mater. Chem. 2011, 21 (12), 4493-4501
34. Rui Guo, Han Wang, Chen Peng, Mingwu Shen, Guixiang Zhang,* Xiangyang Shi*. Enhanced X-Ray Attenuation Property of Dendrimer-Entrapped Gold Nanoparticles Complexed with Diatrizoic Acid. J. Mater. Chem. 2011, 21 (13), 5120-5127
35. Xueyan Cao, Jingjing Chen, Shihui Wen, Chen Peng, Mingwu Shen, and Xiangyang Shi*. Effect of Surface Charge of Polyethyleneimine-Modified Multiwalled Carbon Nanotubes on the Improvement of Polymerase Chain Reaction. Nanoscale 2011, 3 (4), 1741-1747.
36. Hong Yang, Yeming Zhuang, Yun Sun, Antao Dai, Xiangyang Shi,* Dongmei Wu, Fuyou Li, He Hu and Shiping Yang*. Targeted Dual Contrast T1- and T2-weighted Magnetic Resonance Imaging of Tumors using Multifunctional Gadolinium-Labeled Superparamagnetic Iron Oxide Nanoparticles. Biomaterials 2011,32, 4584-4593
37. Yulin Li*, Dina Maciel, Helena Tomás, João Rodrigues, Hui Ma, Xiangyang Shi. pH Sensitive laponite/alginate hybrid hydrogels: swelling behavior and release mechanism. Soft Matter 2011, 7(13), 6231-6238