Amphiphilic hyperbranched polymers carrying two types of b-cyclodextrin groups including
ionic and covalent bonding were synthesized via atom transfer radical polymerization
and immobilization reaction. Their inclusion capabilities for single or double-guest
molecules were investigated by UV-visible spectroscopy.
Using Chlorambucil and Lonidamine as the double model
drugs, their encapsulation efficiencies indicate that these
polymers possess the capabilities of high drug-loading.
Furthermore, the release behaviors of these polymers
were studied via UV-visible spectroscopy. The results
indicate that they can slow the release rate of double
model drugs. Varying the pH values of environment or
regulating their shell layer structures can control the
release behaviors of double model drugs.
