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Synthesis and characterization of a pentaerythritol-based amphiphilic starblock copolymer and its application in controlled drug release  
Synthesis and characterization of a pentaerythritol-based amphiphilic starblock copolymer and its application in controlled drug release
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关键词: star-like  amphiphilic  copolymer  RAFT  polymerization  controlled  drug  
release  
资料大小: 489k
所属学科: 功能高分子
来源: 来源网络
简介:
A star-like amphiphilic copolymer was synthesized via RAFT polymerization by using a pentaerythritolbased compound (PTDBA) as a chain transfer agent with Styrene and DMAEMA as monomers. The polymer structure was characterized by FTIR, 1H NMR, 13C NMR and SEC/MALLS. After the retardation period, the molecular weight of PS-CTA and PMMA-CTA increased linearly with monomer conversion. The amphiphilic copolymer self-assembled into spherical micelles when water was added into its DMF solution. The particle size and polydispersity index (PDI) of the micelles in deionized water were about 406 nm and 0.113, respectively. In a pH 10 buffer solution and low micelle concentration, the micelle size decreased with temperature increase. At higher temperatures and micelle concentrations the size increased, resulting in precipitation among agglomerating micelles. This phenomenon was not observed in deionized water. Furthermore, the copolymer effectively prolonged the release time of chlorambucil (CLB) in deionized water.
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上传时间: 2012-12-04 17:06:34
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