搜索:  
【Bioconjugate Chem. 2016,】Direct Loading and Tunable Release of Antibiotics from Polyelectrolyte Multilayers To Reduce Bacterial Adhesion and Biofilm Formation  
【Bioconjugate Chem. 2016,】Direct Loading and Tunable Release of Antibiotics from Polyelectrolyte Multilayers To Reduce Bacterial Adhesion and Biofilm Formation
资料类型: PDF文件
关键词: antibacterial  layer-by-layer  antibiotics  
资料大小: 570k
所属学科: 功能高分子
来源: 来源网络
简介:
Bacteria adhesion on the surface of biomaterials and following biofilm formation are important problems in biomedical applications. The charged antibiotics with small molar mass can hardly deposit alternately with polymers intomultilayered films to load the drug. Herein, the (poly(acrylic acid)-gentamicin/poly(ethylenimine))n ((PAA-GS/PEI)n)multilayer film was designed and constructed via a layer-by-layer self-assembly method. Low molar mass GS cations were firstcombined with polyanion PAA and self-assembled with PEI to form multilayer films showing exponential growth behavior. TheGS dosage could be adjusted by changing the layer number of films. Furthermore, the thermal cross-linking method was used tocontrol the release rate of GS in PBS buffer. Owing to the diffusion of GS, a zone of inhibition of about 7.0 mm showed theefficient disinfection activity of the multilayer film. It could also be seen from the biofilm inhibition assay that the multilayer filmeffectively inhibited bacterial adhesion and biofilm formation. As the drug loading dosage was 160 μg/cm2, the multilayer films showed very low cytotoxicity against human lens epithelial cells. The present work provides an easy way to load GS intomultilayer films which can be applied to surface modification of implants and biomedical devices.
上传人: wangbailiang
上传时间: 2016-6-12 17:37:30
下载次数: 0
消耗积分: 0  
立即下载:
1人
1人
1人
友情提示:下载后对该资源进行评论,即可奖励2分。
报告错误:  1.下载无效  2. 资料明显无价值  3. 资料重复存在

相关评论 共有0人发表评论 更多评论
你还没有登录,无法发表评论,请首先 登录 注册
免责声明:本站部分资源由网友推荐,来自互联网,版权属于原版权人,如果不慎侵犯到您的权利,敬请告知,我们会在第一时间撤除。本站中各网友的评论只代表其个人观点,不代表本站同意其观点。