研究方向
主要研究领域为生物医用高分子材料的研究。针对人类面临的健康问题，以现代物理及生物学技术为指导，主要运用自组装等非传统的制备技术，设计制备具有特定生物医学应用前景的高分子材料，如高分子自组装薄膜、自组装微胶囊、微凝胶、水凝胶等高分子生物材料。目前的主要研究课题有：
（1）葡萄糖敏感微凝胶/层层自组装膜的设计、制备及其在胰岛素可控释放与葡萄糖传感器领域的应用。其中葡萄糖敏感微凝胶的研究获得了国家自然科学基金的资助。
（2）新型聚合胶态晶体（生物）传感器的研究。本项研究获得了国家自然科学基金的资助。
（3）温度敏感微凝胶溶液的实时胶凝及其用于可注射三维细胞支架材料的研究。本项研究获得了国家科技部国际科技合作项目的资助。
近期代表作：
(1) Chen, M.; Zhang, Y; Jia, Y.; Zhou, L.; Guan, Y.; Zhang, Y.*, Photonic Crystals with a Reversibly Inducible and Erasable Defect State Using External Stimuli. Angew Chem Int Ed 2015, 54(32), 9257-9261.
(2) Chen, M.; Zhou, L.; Guan, Y.; Zhang, Y.*, Polymerized Microgel Colloidal Crystals: Photonic hydrogels with Tunable Bandgap and Fast Response Rate. Angew Chem Int Ed 2013, 52, (38), 9961-9965.
(3) Zhao, Y.; Yuan, Q.; Li, C.; Guan, Y.; Zhang, Y.*, Dynamic layer-by-layer films: a platform for zero-order release, Biomacromolecules 2015, 16(7), 2032-2039.
(4) Zhao, Z.; Gu, J.; Zhao, Y.; Guan, Y.; Zhu, X. X.; Zhang, Y.*, Hydrogel Thin Film with Swelling-Induced Wrinkling Patterns for High-Throughput Generation of Multicellular Spheroids. Biomacromolecules 2014, 15, (9), 3306-3312.
(5) Zhang, X.; Guan, Y.; Zhang, Y.*, Dynamically bonded layer-by-layer films for self-regulated insulin release. Journal of Materials Chemistry 2012, 22, (32), 16299-16305.
(6) Xing, S.; Guan, Y.; Zhang, Y.*, Kinetics of Glucose-Induced Swelling of P(NIPAM-AAPBA) Microgels. Macromolecules 2011, 44, (11), 4479-4486.
(7) Zhang, X.; Guan, Y.; Zhang, Y.*, Ultrathin Hydrogel Films for Rapid Optical Biosensing. Biomacromolecules 2012, 13, (1), 92-97.
(8) Gan, T.; Zhang, Y.*; Guan, Y., In Situ Gelation of P(NIPAM-HEMA) Microgel Dispersion and Its Applications as Injectable 3D Cell Scaffold. Biomacromolecules 2009, 10, (6), 1410-1415.
(9) Wang, D.; Cheng, D.; Guan, Y.; Zhang, Y.*, Thermoreversible Hydrogel for In Situ Generation and Release of HepG2 Spheroids. Biomacromolecules 2011, 12, (3), 578-584.
(10) Gan, T. T.; Guan, Y.; Zhang, Y.*, Thermogelable PNIPAM microgel dispersion as 3D cell scaffold: effect of syneresis. Journal of Materials Chemistry 2010, 20, (28), 5937-5944.
(11) Zhou, L.; Chen, M.; Guan, Y.; Zhang, Y.*, Multiple responsive hydrogel films based on dynamic Schiff base linkages. Polymer Chemistry 2014, 5, 7081-7089.
(12) Tang, Z.; Guan, Y.; Zhang, Y.*, Contraction-type glucose-sensitive microgel functionalized with a 2-substituted phenylboronic acid ligand. Polymer Chemistry 2014, 5, (5), 1782-1790.
