Electrospun core-shell PLLA nanofiber and its potential for drug release，2005年新型纤维与聚合物材料国际学术会议（10.19-10.21，上海）-中国聚合物网,论文下载

Electrospun core-shell PLLA nanofiber and its potential for drug release

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Electrospun core-shell drug release

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分子表征

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2005年新型纤维与聚合物材料国际学术会议（10.19-10.21，上海）

简介：

Electrospinninghasbeendevelopedtofabricatecompositenanofibersforbiomedicalapplicationssuchasdrugdeliverysystemsandtissueengineeringscaffolds.Theobjectiveofthisstudywastoevaluatethephysical–chemicalpropertiesanddrugreleasepropertiesofelectrospuncore-shellpoly(L-lacticacid)(PLLA)fibrousmembranesusedasacontrolledreleasecarriersfortetracyclinehydrochloride(TCH).ThefibrousmembraneswerefabricatedbycoaxialelectrospinninginwhichPLLA(2:1mixtureofchloroformandacetonebyweightasasolvent)andTCH/PLLA(2:1mixtureofmethanolandchloroformbyweightasasolvent)wereusedastheshellandthecorematerials,respectively.Theelectrospunfibersandtheirmembraneswerecharacterizedbyscanningelectronmicroscope(SEM),transmissionelectronmicroscopy(TEM),anddifferentialscanningcalorimetry(DSC),whereasthemechanicalperformancesoffibrousmembranesweretestedthroughtensiletest.ThedrugreleasebehaviorwereinvestigatedbyUV–VISspectroscopy.Resultsindicatedthatthemorphologyoffibersanddistributionoffiberdiameterreliedontheprocessingparameters,andtheuniformcompositefiberswitheminentmechanicalpropertiescouldbeobtainedwhenthecoreandshellsolutionconcentrationswerekeptat5wt%(0.3ml.h-1flowrate)and8-10wt%(5.0ml.h-1flowrate),respectively.TCHcouldbeencapsulatedinthePLLAultrafinefibersandmaintainasustainingreleasefromthefibrousmembranes,suggestingthatthethusobtainedcore-shellcompositefibrousmembranescanbeapromisingcandidatefordrugreleasecarrier.

作者：

C.L. He Z.M Huang L. Liu X.J. Han

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2007-08-07 14:32:37

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