获得专利

1. 孟凤华，徐海飞，钟志远，界面交联的温度敏感的聚合物囊泡及其应用。授权专利号：ZL 2009 1 0030113.5.

2. 李玉玲，刘兆忠，周磊，孟凤华，钟志远，侧链用硫辛酸修饰的亲水性聚合物及其制备和应用。授权专利号：ZL 2009 1 0181922.6.

3. 朱彩虹，罗思彬，孟凤华，朱秀林，钟志远，生物可降解阳离子聚合物及其应用。授权专利号：ZL 2009 1 0232056.9.

4. 陈维，王荣，孟凤华，钟志远，含有丙烯酸酯类功能基团的环碳酸酯单体及其制备和应用。专利申请号：200910181912.2。

5. 刘桂景，李少科，孟凤华，钟志远, 生物可降解聚合物囊泡及其制备和应用。专利申请号：200910264247.3。

6. 钟志远，刘兆忠，郑蒙，孟凤华，一种疏水基团修饰的聚乙烯亚胺衍生物及其应用。专利申请号：201110046746.2.

7. 钟志远, 李玉玲，刘兆忠，周磊，孟凤华，一种侧链用硫辛酸修饰的亲水性聚合物。专利申请号：201110110986.4。

8. Zhiyuan Zhong，Rong Wang, Wei Chen, Fenghua Meng，Method for making an (alkyl) vinyl sulfone based polymer, such (alkyl) vinyl sulfone based polymer, a polymer article and biodevice, cyclic (alkyl) vinyl sulfone carbonate and pegylated cyclic (alkyl) vinyl sulfone carbonate，PCT, filed June 2011.

9. Wei Chen, Rong Wang, Fenghua Meng, and Zhiyuan Zhong, A method of making a polymer preferably an (alkyl)acryloyl polycarbonate, the polymer and (alkyl)acryloyl polycarbonate obtained, and a biodevice comprising same. International Application No. PCT/WO/2011/009478, filed December 2009.

10.   Christine Hiemstra, Zhiyuan Zhong, and Jan Feijen, Stereo Photo Hydrogel, a Process of Making Said Stereo Photo Hydrogel, Polymers for Use in Making Such Hydrogel and a Pharmaceutical Comprising Said Polymers, International Application No. PCT/EP2007/002538, filing date: March 20, 2007.

11. Zhiyuan Zhong, Pieter J. Dijkstra, and Jan Feijen, Branched biodegradable polymers, a macromonomer, processes for the preparation of same, and their use, European Patent, 05.076302.8, filing date: June 3, 2005.

1. Y.J. Jiang, J. Chen, C. Deng*, E. Suuronen, and Z.Y. Zhong*, Click Hydrogels, Microgels and Nanogels: Emerging Platforms for Drug Delivery and Tissue Engineering, Biomaterials  2014, http://dx.doi.org/10.1016/j.biomaterials.2014.03.001.

2. C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications, Prog. Polym. Sci. 2014, 39,330-364.

3. W. Chen, Y. Zou, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Glyco-Nanoparticles with Sheddable Saccharide Shells: A Unique and Potent Platform for Hepatoma-Targeting Delivery of Anticancer Drugs, Biomacromolecules 2014, 15, 900-907.

4. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction and pH Dual-Bioresponsive Crosslinked Polymersomes for Efficient Intracellular Delivery of Proteins and Potent Induction of Cancer Cell Apoptosis, Acta Biomaterialia 2014, http://dx.doi.org/10.1016/j.actbio.2014.01.010

5. F.H. Meng, Y.N. Zhong, R. Cheng, C. Deng, and Z.Y. Zhong*, pH-Sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: Concept and recent advances, Nanomedicine 2014 (in press) (invited feature article)

6. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release, Antioxidants & Redox Signaling 2014, doi:10.1089/ars.2013.5733 (invited forum article)

7. W.W. Guo, M. Zheng, Y.N. Zhong, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Poly(ethylene oxide)-graft-methotrexate Macromolecular Drugs Conjugating via Aminopteridine Ring Exhibit Potent Anticancer Activity, Chinese Journal of Chemistry 2014, 32, 57-65.

8. Y.N. Zhong, W.J. Yang, H.L. Sun, R. Cheng, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells, Biomacromolecules 2013, 14, 3723-3730.

9. J.R. Zhou, P.P. Chen, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, A Simple and Versatile Synthetic Strategy to Functional Polypeptides via Vinyl Sulfone-Substituted L-Cysteine N-Carboxyanhydride, Macromolecules 2013, 46, 6723–6730.

10. Y.P. Fan, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, In Situ Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry, Biomacromolecules 2013, 14, 2814-2821.

11. X.Y. Wang, H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier To Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells, Biomacromolecules 2013, 14, 2873-2882.

12. Y.D. Gu, Y.N. Zhong, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy, Biomacromolecules 2013, 14, 2772-2780.

13. Y.N. Zhong, W. Wang, L. Cheng,  F.H. Meng, Z.Y. Zhong*, and Z. Liu*, Gold Nanorod-Cored Biodegradable Micelles as a Robust and Remotely Controllable Doxorubicin Release System for Potent Inhibition of Drug-Sensitive and -Resistant Cancer Cells, Biomacromolecules 2013, 14, 2411-2419.

14. L.L. Wu, Y. Zou, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Intracellular Release of Doxorubicin from Core-Crosslinked Polypeptide Micelles Triggered by Both pH and Reduction Conditions, Biomaterials 2013, 34, 5262-5272.

15. W. Chen, M. Zheng, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, In Situ Forming Reduction-Sensitive Degradable Nanogels for Facile Loading and Triggered Intracellular Release of Proteins, Biomacromolecules 2013, 14, 1214-1222.

16. H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction-Sensitive Degradable Micellar Nanoparticles as Smart and Intuitive Delivery Systems for Cancer Chemotherapy, Expert Opin. Drug Deliv. 2013, 10, 1109-1122.

17. R. Cheng, F.H. Meng, C. Deng, H.A. Klok, and Z.Y. Zhong*, Dual and Multi-Stimuli Responsive Polymeric Nanoparticles for Programmed Site-Specific Drug Delivery, Biomaterials 2013, 34, 3647-3657.

18. J. Feijen, and Z.Y. Zhong*, The Second Symposium on Innovative Polymers for Controlled Delivery, September 11-14, 2012, Suzhou, China, J. Control. Release 2013, 169, 163-164.

19. W. Chen, P. Zhong, F.H. Meng*, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Redox and pH-Responsive Degradable Micelles for Dually Activated Intracellular Anticancer Drug Release, J. Control. Release 2013, 169, 171-179.

20. J. Feijen, W.E. Hennink?, and Z.Y. Zhong*, Conference Scene: From Innovative Polymers To Advanced Nanomedicine: Key Challenges, Recent Progress and Future Perspectives, Nanomedicine 2013, 8, 177-180.

21. W. Chen, Y. Zou, J.N. Jia, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Functional Poly(ε-caprolactone)s via Copolymerization of ε?Caprolactone and Pyridyl Disulfide-Containing Cyclic Carbonate: Controlled Synthesis and Facile Access to Reduction-Sensitive Biodegradable Graft Copolymer Micelles, Macromolecules 2013, 46, 699-707. 

更多信息请访问钟志远教授的个人主页：http://zhongzhiyuan.polymer.cn/