Nanofibers-based DDS electrospun from co-dissolving solutions of Eudragit L-100 and diclofenac sodium，2009先进纤维与聚合物材料国际学术会议（ICAFPM，10.21-10.24，上海）-中国聚合物网,论文下载

Nanofibers-based DDS electrospun from co-dissolving solutions of Eudragit L-100 and diclofenac sodium

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关键词：

Eudragit L100 Electrospinning Drug-loaded nanofiber Drug delivery
systems colon-targeted

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648K

所属学科：

分子表征

来源：

2009先进纤维与聚合物材料国际学术会议（ICAFPM，10.21-10.24，上海）

简介：

Thepaperpresentsthepreparationandcharacterizationofnanofibers-baseddrugdeliverysystems(DDS)electrospunfromco-dissolvingsolutionsofEudragitL100anddiclofenacsodium(DS).EudragitL-100andDScouldwellco-dissolveinamixedsolventofmethanolanddimethylacetamide(DMAc)withavolumeratioof6to1forpreparingthespinningsolutions.Scanningelectronmicroscope(SEM)wascarriedouttoobservethemorphologyofthenanofibers.Fourier-transforminfrared(FTIR)wasconductedtoclarifytheinteractionsbetweenthedrugandthematrixpolymer.Drugreleaseprofileswereinvestigatedusinginvitrodissolutiontests.ResultsfromSEMshowedthatthedrugwasdistributedevenlyinEudragitL-100nanofibers.FT-IRresultsdemonstratedthatthemaininteractionsbetweenEudragitL-100andDSwerehydrogenbonding.Theinvitrodissolutiontestsshowedthatdrugreleaseratefromdrug-loadednanofibersmainlydependedonthepHvalueofthedissolutionmedia.Drug-loadedEudragitL-100nanofiberscouldbepromisingforpreparingcolon-targetedDDS.

作者：

SHEN Xia-Xia, YU Deng-Guang, BRANFORD-WHITE Chris, ZHU Li-Min

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2010-04-08 17:08:28

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